NutraMeta™ Weight Loss Data Report
Our Research In Metabolic Health
Introduction:
NutraMeta™ is a patented NutraSimilar™ supplement developed for weight management and metabolic health. The patented blend of five ingredients was developed through an AI-driven technique that identified natural ingredients that when combined could support a meaningful improvement in metabolic health without the side effects of synthetic medications. The main areas of research were to evaluate NutraMeta’s™ effect in weight loss, cholesterol lowering, liver fat reduction and how it compared to existing GLP-1RA products.
Study Designs:
The studies were designed by Prostasis with collaboration from Duke University and conducted at Duke facilities. All of these studies evaluated NutraMeta’s™ effect on mice fed with NutraMeta™ and without (Control) using a standard and High Fat Diet (aka – western diet).
Study Results:
In summary, the data suggests that NutraMeta™ had a beneficial effect in all of the metabolic studies conducted in both the High Fat and Low-Fat diets.
In the longer-term weight loss study, mice on NutraMeta™ lost 19% more overall weight than the control high fat dirt group and 35% more fat vs lean muscle mass than the control group.
In the GLP-1RA comparator study, mice on NutraMeta™ lost 9% of their body weight compared to the Control group, GLP-1RA mice lost 12%, and mice on NutraMeta™ and GLP-1RA lost 29% compared to the Control Group equating to a 142% improvement over GLP-1RA alone. The mice on NutraMeta lost substantially less lean muscle mass than mice on GLP-1RA or control.
In the cholesterol study, mice on NutraMeta™ experienced a 28% reduction in total cholesterol versus mice in the control group.
In the liver health study, mice on NutraMeta™ experienced a 45% reduction in liver fat content and a 31% reduction in liver weight vs the control group.
Post Study Hypothesis:
NutraMeta™ works through multiple pathways to improve energy expenditure, preferentially burn fat, reduce cholesterol and improve liver health leading to a reduction in body weight - primarily through loss of fat mass.
Study 1 - Effect On Fat Loss
Introduction:
NutraMeta™ is a patented NutraSimilar™ supplement developed for weight management and metabolic health. The proprietary blend of five natural ingredients was theorized to help manage weight and improve metabolic function.
Study Design:
In this study, we evaluated the effects of NutraMeta™ on the change in body weight when given to obese mice fed a western-style high fat diet (HFD). Obese mice were fed either a HFD alone or a HFD containing NutraMeta™ for 12 weeks. Body weight and body composition was monitored throughout the study.
Study Results:
The study showed that NutraMeta™ produced a significant (19%) and sustained reduction in body weight over the 12 weeks of the study. This difference in body weight was the result of a 35% reduction in fat mass without changes in lean muscle mass.
Post Study Hypothesis:
NutraMeta™ works through multiple mechanisms to improve energy expenditure, reduce inflammation, and preferentially burn fat, leading to a reduction in body weight primarily through loss of fat mass.
Study 2 - Optimizing Exogenous GLP-1
Introduction:
NutraMeta™ is a patented NutraSimilar™ supplement developed for weight management and metabolic health. NutraMeta™ contains five ingredients that are theorized to help manage weight and improve metabolic function by optimizing the actions of an exogenous GLP-1 receptor agonist (GLP-1RA).
Study Design:
In this study, we evaluated the effects of NutraMeta™ on the change in body weight and lean muscle mass of mice treated with or without a GLP-1RA. Mice were randomized into 4 groups; i) placebo, ii) NutraMeta™ diet, iii) GLP-1RA treatment, and iv) NutraMeta™ diet plus GLP-1RA treatment. Mice were monitored daily for 7 days to observe the impact on body weight and body composition.
Study Results:
In comparison to placebo controls, mice on a NutraMeta™ diet lost 9% of body weight, mice treated with a GLP-1RA alone lost 12% of body weight, and the combination of the NutraMeta™ diet with a GLP-1RA produced a 29% reduction of weight loss – equating to a 142% improvement in weight loss over GLP-1RA alone. The decrease in body weight was mostly due to loss of fat mass rather than lean mass as seen in the middle and right charts. The NutraMeta™ alone increased lean muscle mass.
Post Study Hypothesis:
NutraMeta™ is thought to activate several metabolic programs that synergize with a GLP-1RA to reduced body weight. These include systems that may increase energy expenditure in a way that increases fat metabolism. Together, these results suggests that NutraMeta™ could be used as a complementary supplement to optimize GLP-1RA treatment, or as a post-GLP-1RA supplement to sustain weight loss.
Study 3 - Effect On Cholesterol
Introduction:
NutraMeta™ is a patented NutraSimilar™ supplement developed for weight management and metabolic health. NutraMeta™ is theorized to help reduce cholesterol levels.
Study Design:
In this study, we measured the effects of NutraMeta™ on the change in cholesterol levels in mice fed both a western. High Fat Diet (HFD) with NutraMeta™ and without. After 12 weeks blood was collected to measure levels of cholesterol.
Study Results:
The study showed that NutraMeta™ produced a 28% reduction in cholesterol levels in mice on the HFD compared to the control group.
Post Study Hypothesis:
NutraMeta™ works through multiple mechanisms to improve energy efficiency, preferentially burning fat, and reducing weight, resulting in reduction in cholesterol levels.
Study 4 - Effect On Liver Health
Introduction:
NutraMeta™ is a patented NutraSimilar™ supplement that includes 5 ingredients developed for weight management and metabolic health. NutraMeta is theorized to help manage weight and improve liver health.
Study Design:
In this study, we evaluated the effects of NutraMeta™ on liver weight and liver fat content in obese mice. Mice were fed a high fat diet (HFD) that resembles a western-style diet to induce obesity and liver disease. After which, the mice were randomly assigned to continue the HFD alone or fed a HFD supplemented with NutraMeta . After 12 weeks the livers were weighed and evaluated for fat composition.
Study Results:
The study showed that NutraMeta™ reduced liver fat content by 45% (left chart) along with a 31% reduction in liver weight (right chart).
Post Study Hypothesis:
NutraMeta™ works through multiple mechanisms to improve energy efficiency, preferentially burning fat and reducing weight. This effect has a positive impact on liver health.